Type I interferon pathway in adult and juvenile dermatomyositis
نویسندگان
چکیده
منابع مشابه
Type I interferon pathway in adult and juvenile dermatomyositis
Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added ad...
متن کاملSevere dermatomyositis triggered by interferon beta-1a therapy and associated with enhanced type I interferon signaling.
BACKGROUND Type I interferons (IFNs) are common therapeutics for several diseases, including viral infections and multiple sclerosis (MS). Although numerous studies have implicated type I INFs with the production of autoantibodies and the development of certain autoimmune disorders, interferon beta has not previously been described in association with dermatomyositis, to our knowledge. Previous...
متن کاملSkeletal muscle major histocompatibility complex class I and II expression differences in adult and juvenile dermatomyositis
OBJECTIVE To analyze major histocompatibility complex expression in the muscle fibers of juvenile and adult dermatomyositis. METHOD In total, 28 untreated adult dermatomyositis patients, 28 juvenile dermatomyositis patients (Bohan and Peter's criteria) and a control group consisting of four dystrophic and five Pompe's disease patients were analyzed. Routine histological and immunohistochemica...
متن کاملClinical Characteristics and Outcomes of Juvenile and Adult Dermatomyositis
Dermatomyositis (DM) is an idiopathic inflammatory myopathy with bimodal onset age distribution. The age of onset is between 5-18 yr in juvenile DM and 45-64 yr in adult DM. DM has a distinct clinical manifestation characterized by proximal muscle weakness, skin rash, extramuscular manifestations (joint contracture, dysphagia, cardiac disturbances, pulmonary symptoms, subcutaneous calcification...
متن کاملJuvenile dermatomyositis.
Juvenile dermatomyositis (JDMS) is a chronic inflammatory condition characterized by muscle weakness and a distinctive rash caused by underlying vasculopathy. Long-term complications include subcutaneous and muscular calcification, contractures and in some cases the gradual development of a second connective tissue disease. Early aggressive treatment with systemic immunosuppressants and other a...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2011
ISSN: 1478-6354
DOI: 10.1186/ar3531